Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission

Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission

Cellular signalling networks provide information to the cell, but the trade-off between accuracy of information transfer and energetic cost of doing so has not been assessed. Here, the authors investigate a MAPK signalling cascade in budding yeast and find that information is maximised per unit ener...

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Bibliographic Details
Main Authors: Alexander Anders, Bhaswar Ghosh, Timo Glatter, Victor Sourjik
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17276-4
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spelling doaj-7f787051a74d42e59c4e8edc6107be9e2021-07-18T11:45:02ZengNature Publishing GroupNature Communications2041-17232020-07-0111111010.1038/s41467-020-17276-4Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmissionAlexander Anders0Bhaswar Ghosh1Timo Glatter2Victor Sourjik3Max Planck Institute for Terrestrial MicrobiologyMax Planck Institute for Terrestrial MicrobiologyMax Planck Institute for Terrestrial MicrobiologyMax Planck Institute for Terrestrial MicrobiologyCellular signalling networks provide information to the cell, but the trade-off between accuracy of information transfer and energetic cost of doing so has not been assessed. Here, the authors investigate a MAPK signalling cascade in budding yeast and find that information is maximised per unit energetic cost.https://doi.org/10.1038/s41467-020-17276-4
collection DOAJ
language English
format Article
sources DOAJ
author Alexander Anders
Bhaswar Ghosh
Timo Glatter
Victor Sourjik
spellingShingle Alexander Anders
Bhaswar Ghosh
Timo Glatter
Victor Sourjik
Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
Nature Communications
author_facet Alexander Anders
Bhaswar Ghosh
Timo Glatter
Victor Sourjik
author_sort Alexander Anders
title Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
title_short Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
title_full Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
title_fullStr Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
title_full_unstemmed Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission
title_sort design of a mapk signalling cascade balances energetic cost versus accuracy of information transmission
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Cellular signalling networks provide information to the cell, but the trade-off between accuracy of information transfer and energetic cost of doing so has not been assessed. Here, the authors investigate a MAPK signalling cascade in budding yeast and find that information is maximised per unit energetic cost.
url https://doi.org/10.1038/s41467-020-17276-4
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AT timoglatter designofamapksignallingcascadebalancesenergeticcostversusaccuracyofinformationtransmission
AT victorsourjik designofamapksignallingcascadebalancesenergeticcostversusaccuracyofinformationtransmission
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