Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.

Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrPC. Prions cause disease by converting PrPC into aggregation-prone PrPSc. Chronic wasting disease (CWD) is the most contagious prion disease with substantial late...

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Bibliographic Details
Main Authors:	Samia Hannaoui, Sara Amidian, Yo Ching Cheng, Camilo Duque Velásquez, Lyudmyla Dorosh, Sampson Law, Glenn Telling, Maria Stepanova, Debbie McKenzie, Holger Wille, Sabine Gilch
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-08-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC5568445?pdf=render

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