Phage Therapy: Beyond Antibacterial Action

Until recently, phages were considered as mere “bacteria eaters” with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical trials. However, the progress in research on p...

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Main Authors:	Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Marzanna Łusiak-Szelachowska, Natalia Bagińska, Jan Borysowski, Małgorzata B. Łobocka, Alicja Węgrzyn, Grzegorz Węgrzyn
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Medicine
Subjects:	phage phage therapy immunomodulation inflammation prophage induction
Online Access:	https://www.frontiersin.org/article/10.3389/fmed.2018.00146/full

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spelling	doaj-7f5687ddec264ea9897457ca9b3395f72020-11-24T21:10:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-05-01510.3389/fmed.2018.00146369809Phage Therapy: Beyond Antibacterial ActionAndrzej Górski0Andrzej Górski1Andrzej Górski2Ewa Jończyk-Matysiak3Ryszard Międzybrodzki4Ryszard Międzybrodzki5Ryszard Międzybrodzki6Beata Weber-Dąbrowska7Beata Weber-Dąbrowska8Marzanna Łusiak-Szelachowska9Natalia Bagińska10Jan Borysowski11Małgorzata B. Łobocka12Małgorzata B. Łobocka13Alicja Węgrzyn14Grzegorz Węgrzyn15Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandPhage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, PolandDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, PolandAutonomous Department of Microbial Biology, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw, PolandLaboratory of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Gdańsk, PolandDepartment of Molecular Biology, University of Gdańsk, Gdańsk, PolandUntil recently, phages were considered as mere “bacteria eaters” with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical trials. However, the progress in research on phage biology has shed more light on the significance of phages. Accumulating data indicate that phages may also interact with eukaryotic cells. How such interactions could be translated into advances in medicine (especially novel means of therapy) is discussed herein.https://www.frontiersin.org/article/10.3389/fmed.2018.00146/fullphagephage therapyimmunomodulationinflammationprophage induction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrzej Górski Andrzej Górski Andrzej Górski Ewa Jończyk-Matysiak Ryszard Międzybrodzki Ryszard Międzybrodzki Ryszard Międzybrodzki Beata Weber-Dąbrowska Beata Weber-Dąbrowska Marzanna Łusiak-Szelachowska Natalia Bagińska Jan Borysowski Małgorzata B. Łobocka Małgorzata B. Łobocka Alicja Węgrzyn Grzegorz Węgrzyn
spellingShingle	Andrzej Górski Andrzej Górski Andrzej Górski Ewa Jończyk-Matysiak Ryszard Międzybrodzki Ryszard Międzybrodzki Ryszard Międzybrodzki Beata Weber-Dąbrowska Beata Weber-Dąbrowska Marzanna Łusiak-Szelachowska Natalia Bagińska Jan Borysowski Małgorzata B. Łobocka Małgorzata B. Łobocka Alicja Węgrzyn Grzegorz Węgrzyn Phage Therapy: Beyond Antibacterial Action Frontiers in Medicine phage phage therapy immunomodulation inflammation prophage induction
author_facet	Andrzej Górski Andrzej Górski Andrzej Górski Ewa Jończyk-Matysiak Ryszard Międzybrodzki Ryszard Międzybrodzki Ryszard Międzybrodzki Beata Weber-Dąbrowska Beata Weber-Dąbrowska Marzanna Łusiak-Szelachowska Natalia Bagińska Jan Borysowski Małgorzata B. Łobocka Małgorzata B. Łobocka Alicja Węgrzyn Grzegorz Węgrzyn
author_sort	Andrzej Górski
title	Phage Therapy: Beyond Antibacterial Action
title_short	Phage Therapy: Beyond Antibacterial Action
title_full	Phage Therapy: Beyond Antibacterial Action
title_fullStr	Phage Therapy: Beyond Antibacterial Action
title_full_unstemmed	Phage Therapy: Beyond Antibacterial Action
title_sort	phage therapy: beyond antibacterial action
publisher	Frontiers Media S.A.
series	Frontiers in Medicine
issn	2296-858X
publishDate	2018-05-01
description	Until recently, phages were considered as mere “bacteria eaters” with potential for use in combating antimicrobial resistance. The real value of phage therapy assessed according to the standards of evidence-based medicine awaits confirmation by clinical trials. However, the progress in research on phage biology has shed more light on the significance of phages. Accumulating data indicate that phages may also interact with eukaryotic cells. How such interactions could be translated into advances in medicine (especially novel means of therapy) is discussed herein.
topic	phage phage therapy immunomodulation inflammation prophage induction
url	https://www.frontiersin.org/article/10.3389/fmed.2018.00146/full
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Phage Therapy: Beyond Antibacterial Action

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