Periodicity and dosage optimization of an RNAi model in eukaryotes cells

Periodicity and dosage optimization of an RNAi model in eukaryotes cells

Abstract Background As a highly efficient and specific gene regulation technology, RNAi has broad application fields and good prospects. The effect of RNAi enhances as the dosage of siRNA increases, while an exorbitant siRNA dosage will inhibit the RNAi effect. So it is crucial to formulate a dose-e...

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Bibliographic Details
Main Authors: Tongle Ma, Yongzhen Pei, Changguo Li, Meixia Zhu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Bioinformatics
Subjects:
RNA interference
Delay
Oscillation period
Sensitivity analyse
Optimal control
Online Access:http://link.springer.com/article/10.1186/s12859-019-2925-z

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http://link.springer.com/article/10.1186/s12859-019-2925-z

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