Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology.

Ultra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technology.

In order to investigate the potential of voles to reproduce in vitro the efficiency of prion replication previously observed in vivo, we seeded protein misfolding cyclic amplification (PMCA) reactions with either rodent-adapted Transmissible Spongiform Encephalopathy (TSE) strains or natural TSE iso...

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Bibliographic Details
Main Authors:	Gian Mario Cosseddu, Romolo Nonno, Gabriele Vaccari, Cecilia Bucalossi, Natalia Fernandez-Borges, Michele Angelo Di Bari, Joaquin Castilla, Umberto Agrimi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-11-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC3219717?pdf=render

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