Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities

Diabetes mellitus is the most common chronic disorder and leading cause of renal, neurological, and gastrointestinal manifestations in developed and developing countries. Despite of many drugs and combinational therapies, the complications of diabetes are still listed due to severe consequences of t...

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Main Authors: Hafiza Salaha Mahrosh, Rizwan Mehmood, Shazia Anwer Bukhari, Gulnaz Afzal, Rawaba Arif
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2021/5550180
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spelling doaj-7f45affa8ec6444ea8e842c581a49e5e2021-06-21T02:25:16ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/5550180Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic ActivitiesHafiza Salaha Mahrosh0Rizwan Mehmood1Shazia Anwer Bukhari2Gulnaz Afzal3Rawaba Arif4Department of BiochemistryDepartment of BiochemistryDepartment of BiochemistryDepartment of ZoologyDepartment of BiochemistryDiabetes mellitus is the most common chronic disorder and leading cause of renal, neurological, and gastrointestinal manifestations in developed and developing countries. Despite of many drugs and combinational therapies, the complications of diabetes are still listed due to severe consequences of those drugs. In past few years, plant-derived drugs draw special attention due to their higher efficacy and fewer side-effects. Momordica charantia also known as bitter melon is referred as an antidiabetic and hypoglycemic plant in native populations of Asia and East Africa. In current study, an in silico approach was used to evaluate the interactions and binding patterns of plant-derived peptides devised from a hypoglycemic protein adMc1 of M. charantia as potential inhibitor of DPP-IV, SGLT1, and GLUT2 receptor proteins. The study has described a novel approach to investigate hypoglycemic peptides to cure diabetes. A total of eighty tetra-, penta-, and hexapeptides were devised from conserved regions of adMc1 homologs. The molecular docking approach using MOE software was employed to reveal inhibiting potentials of devised peptides against three selected proteins. Out of 30 shortlisted ligands six peptides (i.e. SMCG, DECC, TTIT, RTTI, ARNL and TVEV) accomplished the criteria of being good drug candidates against selected receptor proteins following the drugability assessment test. The overall results are acceptable on the basis of ADMET profiling for being good drug candidates against selected proteins.http://dx.doi.org/10.1155/2021/5550180
collection DOAJ
language English
format Article
sources DOAJ
author Hafiza Salaha Mahrosh
Rizwan Mehmood
Shazia Anwer Bukhari
Gulnaz Afzal
Rawaba Arif
spellingShingle Hafiza Salaha Mahrosh
Rizwan Mehmood
Shazia Anwer Bukhari
Gulnaz Afzal
Rawaba Arif
Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
BioMed Research International
author_facet Hafiza Salaha Mahrosh
Rizwan Mehmood
Shazia Anwer Bukhari
Gulnaz Afzal
Rawaba Arif
author_sort Hafiza Salaha Mahrosh
title Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
title_short Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
title_full Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
title_fullStr Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
title_full_unstemmed Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities
title_sort investigation of hypoglycemic peptides derived from conserved regions of admc1 to reveal their antidiabetic activities
publisher Hindawi Limited
series BioMed Research International
issn 2314-6141
publishDate 2021-01-01
description Diabetes mellitus is the most common chronic disorder and leading cause of renal, neurological, and gastrointestinal manifestations in developed and developing countries. Despite of many drugs and combinational therapies, the complications of diabetes are still listed due to severe consequences of those drugs. In past few years, plant-derived drugs draw special attention due to their higher efficacy and fewer side-effects. Momordica charantia also known as bitter melon is referred as an antidiabetic and hypoglycemic plant in native populations of Asia and East Africa. In current study, an in silico approach was used to evaluate the interactions and binding patterns of plant-derived peptides devised from a hypoglycemic protein adMc1 of M. charantia as potential inhibitor of DPP-IV, SGLT1, and GLUT2 receptor proteins. The study has described a novel approach to investigate hypoglycemic peptides to cure diabetes. A total of eighty tetra-, penta-, and hexapeptides were devised from conserved regions of adMc1 homologs. The molecular docking approach using MOE software was employed to reveal inhibiting potentials of devised peptides against three selected proteins. Out of 30 shortlisted ligands six peptides (i.e. SMCG, DECC, TTIT, RTTI, ARNL and TVEV) accomplished the criteria of being good drug candidates against selected receptor proteins following the drugability assessment test. The overall results are acceptable on the basis of ADMET profiling for being good drug candidates against selected proteins.
url http://dx.doi.org/10.1155/2021/5550180
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