The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer

Summary: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental...

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Bibliographic Details
Main Authors:	Nicolas Veland, Swanand Hardikar, Yi Zhong, Sitaram Gayatri, Jiameng Dan, Brian D. Strahl, Scott B. Rothbart, Mark T. Bedford, Taiping Chen
Format:	Article
Language:	English
Published:	Elsevier 2017-12-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717317497

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