Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases

Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases

Gliomas are the most common and malignant primary brain tumors in humans. Studies have shown that classes of kaurene diterpene have anti-tumor activity related to their ability to induce apoptosis. We investigated the response of the human glioblastoma cell line U87 to treatment with...

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Bibliographic Details
Main Authors: F.S. Lizarte Neto, D.P.C. Tirapelli, S.R. Ambrosio, C.R. Tirapelli, F.M. Oliveira, P.C. Novais, F.M. Peria, H.F. Oliveira, C.G. Carlotti Junior, L.F. Tirapelli
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Kaurenoic acid
Glioblastoma
miR-21
c-FLIP
Apoptosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100071&lng=en&tlng=en

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