Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression

Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression

Background: Myocardial fibrosis is an important pathological feature of pressure overload cardiac remodeling. Si-Miao-Yong-An decoction (SMYAD), a traditional Chinese formula, is now clinically used in the treatment of cardiovascular diseases in China. However, its mechanisms in the prevention of he...

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Bibliographic Details
Main Authors: Congping Su, Qing Wang, Hui Luo, Wenchao Jiao, Jiayang Tang, Lin Li, Lei Tian, Xiangyang Chen, Bin Liu, Xue Yu, Sen Li, Shuzhen Guo, Wei Wang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Si-Miao-Yong-An decoction
Cardiac fibrosis
Transverse aorta constriction
TGF-β
Matrix metalloproteinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303243

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http://www.sciencedirect.com/science/article/pii/S0753332220303243

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