Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic ste...
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Bibliographic Details
| Main Authors: |
Lars Velten,
Benjamin A. Story,
Pablo Hernández-Malmierca,
Simon Raffel,
Daniel R. Leonce,
Jennifer Milbank,
Malte Paulsen,
Aykut Demir,
Chelsea Szu-Tu,
Robert Frömel,
Christoph Lutz,
Daniel Nowak,
Johann-Christoph Jann,
Caroline Pabst,
Tobias Boch,
Wolf-Karsten Hofmann,
Carsten Müller-Tidow,
Andreas Trumpp,
Simon Haas,
Lars M. Steinmetz |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21650-1
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