Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.

Sustained pressure overload leads to compensatory myocardial hypertrophy and subsequent heart failure, a leading cause of morbidity and mortality. Further unraveling of the cellular processes involved is essential for development of new treatment strategies. We have investigated the hypothesis that...

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Bibliographic Details
Main Authors: Alexandra V Finsen, Ida G Lunde, Ivar Sjaastad, Even K Østli, Marianne Lyngra, Hilde O Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A Wilcox-Adelman, Paul F Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E Louch, Srdjan Djurovic, Cathrine R Carlson, Geir Christensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3229559?pdf=render

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