Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission

Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission

We report a patient with diffuse large B-cell lymphoma of skin, nongerminal center type double hit double expressor, with an initial presentation as a left forearm mass. The patient underwent chemotherapy after initial diagnosis. After chemotherapy regimen, she developed a second mass, followed by C...

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Main Authors: Brenda S. Castillo, Maria L. Rodriguez, Ju-Hsien John Chao, Behyar Zoghi
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2019/3953470
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spelling doaj-7f2f6ed82ce143baaa7de12420f74a332020-11-25T00:12:02ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/39534703953470Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to RemissionBrenda S. Castillo0Maria L. Rodriguez1Ju-Hsien John Chao2Behyar Zoghi3Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas, USABrown University, Providence, RI, USAMethodist Hospital, Texas Transplant Institute, San Antonio, Texas, USAMethodist Hospital, Texas Transplant Institute, San Antonio, Texas, USAWe report a patient with diffuse large B-cell lymphoma of skin, nongerminal center type double hit double expressor, with an initial presentation as a left forearm mass. The patient underwent chemotherapy after initial diagnosis. After chemotherapy regimen, she developed a second mass, followed by CNS involvement with neurological defects. At this time, a three line of chemotherapy was used with minimal effects. The patient was deemed terminal and was recommended hospice care. The patient decided to continue with skin and crainospinal radiotherapy and intrathecal chemotherapy; she achieved complete remission. After achieving complete remission, the patient underwent an autologous stem cell transplant with minimal transplant-related toxicity.http://dx.doi.org/10.1155/2019/3953470
collection DOAJ
language English
format Article
sources DOAJ
author Brenda S. Castillo
Maria L. Rodriguez
Ju-Hsien John Chao
Behyar Zoghi
spellingShingle Brenda S. Castillo
Maria L. Rodriguez
Ju-Hsien John Chao
Behyar Zoghi
Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
Case Reports in Hematology
author_facet Brenda S. Castillo
Maria L. Rodriguez
Ju-Hsien John Chao
Behyar Zoghi
author_sort Brenda S. Castillo
title Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
title_short Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
title_full Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
title_fullStr Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
title_full_unstemmed Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission
title_sort primary cutaneous diffuse large b-cell lymphoma of the upper limb: double hit/double expressor with cns involvement: from hospice to remission
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2019-01-01
description We report a patient with diffuse large B-cell lymphoma of skin, nongerminal center type double hit double expressor, with an initial presentation as a left forearm mass. The patient underwent chemotherapy after initial diagnosis. After chemotherapy regimen, she developed a second mass, followed by CNS involvement with neurological defects. At this time, a three line of chemotherapy was used with minimal effects. The patient was deemed terminal and was recommended hospice care. The patient decided to continue with skin and crainospinal radiotherapy and intrathecal chemotherapy; she achieved complete remission. After achieving complete remission, the patient underwent an autologous stem cell transplant with minimal transplant-related toxicity.
url http://dx.doi.org/10.1155/2019/3953470
work_keys_str_mv AT brendascastillo primarycutaneousdiffuselargebcelllymphomaoftheupperlimbdoublehitdoubleexpressorwithcnsinvolvementfromhospicetoremission
AT marialrodriguez primarycutaneousdiffuselargebcelllymphomaoftheupperlimbdoublehitdoubleexpressorwithcnsinvolvementfromhospicetoremission
AT juhsienjohnchao primarycutaneousdiffuselargebcelllymphomaoftheupperlimbdoublehitdoubleexpressorwithcnsinvolvementfromhospicetoremission
AT behyarzoghi primarycutaneousdiffuselargebcelllymphomaoftheupperlimbdoublehitdoubleexpressorwithcnsinvolvementfromhospicetoremission
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