Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), likely contribute to complications of Alzheimer’s disease (AD). The AD triple transgenic mouse model (3xTg...

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Bibliographic Details
Main Authors: Ibrahim eGonzález Marrero, Lydia eGiménez Llort, Conrad E. eJohanson, Emilia María eCarmona Calero, Leandro eCastañeyra Ruiz, José Miguel eBrito Armas, Agustín eCastañeyra Perdomo, Rafael eCastro-Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Choroid Plexus
Alzheimer´s disease
amyloid-β
dysfunction
transthyretin
aquaporin-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00017/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00017/full

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