Inflammation in Chronic Wounds
Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous...
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MDPI AG
2016-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/12/2085 |
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doaj-7f22474fbdd247f5a9088ca20fedae9a2020-11-25T02:48:02ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712208510.3390/ijms17122085ijms17122085Inflammation in Chronic WoundsRuilong Zhao0Helena Liang1Elizabeth Clarke2Christopher Jackson3Meilang Xue4Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, AustraliaSutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, AustraliaMurray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, AustraliaSutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, AustraliaSutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, AustraliaNon-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.http://www.mdpi.com/1422-0067/17/12/2085chronic woundinflammationvenous ulcerarterial ulcerpressure ulcerdiabetic ulcerageinghypoxiaischaemia-reperfusionbacterial colonisation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ruilong Zhao Helena Liang Elizabeth Clarke Christopher Jackson Meilang Xue |
| spellingShingle |
Ruilong Zhao Helena Liang Elizabeth Clarke Christopher Jackson Meilang Xue Inflammation in Chronic Wounds International Journal of Molecular Sciences chronic wound inflammation venous ulcer arterial ulcer pressure ulcer diabetic ulcer ageing hypoxia ischaemia-reperfusion bacterial colonisation |
| author_facet |
Ruilong Zhao Helena Liang Elizabeth Clarke Christopher Jackson Meilang Xue |
| author_sort |
Ruilong Zhao |
| title |
Inflammation in Chronic Wounds |
| title_short |
Inflammation in Chronic Wounds |
| title_full |
Inflammation in Chronic Wounds |
| title_fullStr |
Inflammation in Chronic Wounds |
| title_full_unstemmed |
Inflammation in Chronic Wounds |
| title_sort |
inflammation in chronic wounds |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2016-12-01 |
| description |
Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research. |
| topic |
chronic wound inflammation venous ulcer arterial ulcer pressure ulcer diabetic ulcer ageing hypoxia ischaemia-reperfusion bacterial colonisation |
| url |
http://www.mdpi.com/1422-0067/17/12/2085 |
| work_keys_str_mv |
AT ruilongzhao inflammationinchronicwounds AT helenaliang inflammationinchronicwounds AT elizabethclarke inflammationinchronicwounds AT christopherjackson inflammationinchronicwounds AT meilangxue inflammationinchronicwounds |
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