Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy.

Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy.

To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral doxycycline. The mice developed muscle weakness a...

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Bibliographic Details
Main Authors: Jigna Narola, Sachchida Nand Pandey, Adam Glick, Yi-Wen Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3828351?pdf=render

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