Aged interleukin-10tm1Cgn chronically inflamed mice have substantially reduced fat mass, metabolic rate, and adipokines.

Aged interleukin-10tm1Cgn chronically inflamed mice have substantially reduced fat mass, metabolic rate, and adipokines.

Interleukin 10tm1Cgn (IL 10tm) mice have been utilized as a model of chronic inflammation and declining health span because of their propensity to develop chronic activation in NFkB pathways, skeletal muscle and cardiac changes, and mitochondrial dysfunction. We hypothesized that older IL 10tm frail...

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Bibliographic Details
Main Authors: Reyhan M Westbrook, Huan Le Yang, Jackie M Langdon, Cindy N Roy, Jin A Kim, Parichoy P Choudhury, Qian-Li Xue, Andrea di Francesco, Rafa de Cabo, Jeremy Walston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5739384?pdf=render

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