The Role of GSH in Intracellular Iron Trafficking

The Role of GSH in Intracellular Iron Trafficking

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in...

Full description

Bibliographic Details
Main Authors: Robert Hider, Mayra Vera Aviles, Yu-Lin Chen, Gladys Oluyemisi Latunde-Dada
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
cytosol
labile iron
glutathione
histidine
carnosine
Online Access:https://www.mdpi.com/1422-0067/22/3/1278
id doaj-7f0eddbdab0447c88f57a3f270632b25
record_format Article
spelling doaj-7f0eddbdab0447c88f57a3f270632b252021-01-29T00:02:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01221278127810.3390/ijms22031278The Role of GSH in Intracellular Iron TraffickingRobert Hider0Mayra Vera Aviles1Yu-Lin Chen2Gladys Oluyemisi Latunde-Dada3Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKEvidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.https://www.mdpi.com/1422-0067/22/3/1278cytosollabile ironglutathionehistidinecarnosine
collection DOAJ
language English
format Article
sources DOAJ
author Robert Hider
Mayra Vera Aviles
Yu-Lin Chen
Gladys Oluyemisi Latunde-Dada
spellingShingle Robert Hider
Mayra Vera Aviles
Yu-Lin Chen
Gladys Oluyemisi Latunde-Dada
The Role of GSH in Intracellular Iron Trafficking
International Journal of Molecular Sciences
cytosol
labile iron
glutathione
histidine
carnosine
author_facet Robert Hider
Mayra Vera Aviles
Yu-Lin Chen
Gladys Oluyemisi Latunde-Dada
author_sort Robert Hider
title The Role of GSH in Intracellular Iron Trafficking
title_short The Role of GSH in Intracellular Iron Trafficking
title_full The Role of GSH in Intracellular Iron Trafficking
title_fullStr The Role of GSH in Intracellular Iron Trafficking
title_full_unstemmed The Role of GSH in Intracellular Iron Trafficking
title_sort role of gsh in intracellular iron trafficking
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-01-01
description Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.
topic cytosol
labile iron
glutathione
histidine
carnosine
url https://www.mdpi.com/1422-0067/22/3/1278
work_keys_str_mv AT roberthider theroleofgshinintracellularirontrafficking
AT mayraveraaviles theroleofgshinintracellularirontrafficking
AT yulinchen theroleofgshinintracellularirontrafficking
AT gladysoluyemisilatundedada theroleofgshinintracellularirontrafficking
AT roberthider roleofgshinintracellularirontrafficking
AT mayraveraaviles roleofgshinintracellularirontrafficking
AT yulinchen roleofgshinintracellularirontrafficking
AT gladysoluyemisilatundedada roleofgshinintracellularirontrafficking
_version_ 1724319293561110528

Similar Items