Community-Acquired Methicillin-Resistant Staphylococcus aureus ST59 in a Chinese Adult with Meningitis: A Case Report from China

• Main Authors: Chen F, Chen Y, Zhao X, Wang J
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-06-01
• Series: Infection and Drug Resistance
• Subjects: methicillin-resistant staphylococcus aureus; community-acquired; meningitis; whole-genome sequencing; st59
• Online Access: https://www.dovepress.com/community-acquired-methicillin-resistant-staphylococcus-aureus-st59-in-peer-reviewed-article-IDR

Fayu Chen,1 Yan Chen,2 Xiaofei Zhao,3 Jianfeng Wang4 1Department of General Practice, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of General Practice, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 4Department of Respiratory Diseases, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Jianfeng WangDepartment of Respiratory Diseases, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of ChinaTel [phone]Email [e-mail]: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed by cerebrospinal fluid examination. Whole-genome sequencing data revealed an ST59 CA-MRSA strain encoding PVL and SCCmec IV. Linezolid was administered in this case, and the patient recovered, with no signs of relapse during the one-year follow-up. We present the first case of PVL-positive ST59 CA-MRSA meningitis, with severe manifestations in China.Keywords: methicillin-resistant Staphylococcus aureus, community-acquired, meningitis, whole-genome sequencing, ST59