Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

The Wnt and Hippo pathways are tightly coordinated and understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of Wnt and is now in a phase II trial for advanced colorectal cancer (CRC) patients. We found th...

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Bibliographic Details
Main Authors: Hee Eun Kang, Yoojeong Seo, Jun Seop Yun, Sang Hyun Song, Dawool Han, Eunae Sandra Cho, Sue Bean Cho, Yoon Jeon, Ho Lee, Hyun Sil Kim, Joyeon Kang, Jong In Yook, Nam Hee Kim, Tae Il Kim
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
colorectal cancer
Wnt
Hippo
niclosamide
metformin
Online Access:https://www.mdpi.com/2072-6694/13/14/3437

Internet

https://www.mdpi.com/2072-6694/13/14/3437

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