| Summary: | The purpose of work was to determine the morphological chages in submandibular salivary gland and liver after experimental cadmium chloride treatment. 50 white rats were treated by cadmium chloride in a dose 1200 mcg/| 100 g of body weight during 10 days. The pieces of gland and liver were used for histological examination on the 1, 7, 14, 21, 28 day. The dystrophic changes of parenchyma and stroma of the liver and submandibular salivary gland with different degree of lesion are observed during the cadmium intoxication. The toxic hepatitis was diagnosed, the signs of sialadenitis prevailed in submandibular salivary gland. Liver reacts earlier on cadmium intoxication and part of its functional elements, exactly hepatocytes of the central zone of lobuli, undergo necrotic changes. The character of morphological changes in a liver suggests the influence of surplus of free radicals and insufficient antioxidant defence. The patomorphological changes in organs progress after stopping of toxic treatment.
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