Microglia as therapeutic target in central nervous system disorders

Chronic microglial activation is associated with the pathogenesis of several CNS disorders. Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus, understanding the pathology-specific heterogeneity of microglial behavior is crucial for the future development of microgli...

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Main Authors:	Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita
Format:	Article
Language:	English
Published:	Elsevier 2020-11-01
Series:	Journal of Pharmacological Sciences
Subjects:	Microglial activation Phenotypes Homeostasis Heterogeneity CNS disorders
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861320300682

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spelling	doaj-7ef5e6bd038a4d6f92e56c055117f4052020-11-25T01:55:10ZengElsevierJournal of Pharmacological Sciences1347-86132020-11-011443102118Microglia as therapeutic target in central nervous system disordersOluwaseun Fatoba0Takahide Itokazu1Toshihide Yamashita2Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; WPI-Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Corresponding author. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Neuro-Medical Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; WPI-Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Neuro-Medical Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Corresponding author. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.Chronic microglial activation is associated with the pathogenesis of several CNS disorders. Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus, understanding the pathology-specific heterogeneity of microglial behavior is crucial for the future development of microglia-modulating therapy for variety of CNS disorders. This review summarizes up-to-date knowledge on how microglia contribute to CNS homeostasis during development and throughout adulthood. We discuss the heterogeneity of microglial phenotypes in the context of CNS disorders with an emphasis on neurodegenerative diseases, demyelinating diseases, CNS trauma, and epilepsy. We conclude this review with a discussion about the disease-specific heterogeneity of microglial function and how it could be exploited for therapeutic intervention.http://www.sciencedirect.com/science/article/pii/S1347861320300682Microglial activationPhenotypesHomeostasisHeterogeneityCNS disorders
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Oluwaseun Fatoba Takahide Itokazu Toshihide Yamashita
spellingShingle	Oluwaseun Fatoba Takahide Itokazu Toshihide Yamashita Microglia as therapeutic target in central nervous system disorders Journal of Pharmacological Sciences Microglial activation Phenotypes Homeostasis Heterogeneity CNS disorders
author_facet	Oluwaseun Fatoba Takahide Itokazu Toshihide Yamashita
author_sort	Oluwaseun Fatoba
title	Microglia as therapeutic target in central nervous system disorders
title_short	Microglia as therapeutic target in central nervous system disorders
title_full	Microglia as therapeutic target in central nervous system disorders
title_fullStr	Microglia as therapeutic target in central nervous system disorders
title_full_unstemmed	Microglia as therapeutic target in central nervous system disorders
title_sort	microglia as therapeutic target in central nervous system disorders
publisher	Elsevier
series	Journal of Pharmacological Sciences
issn	1347-8613
publishDate	2020-11-01
description	Chronic microglial activation is associated with the pathogenesis of several CNS disorders. Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus, understanding the pathology-specific heterogeneity of microglial behavior is crucial for the future development of microglia-modulating therapy for variety of CNS disorders. This review summarizes up-to-date knowledge on how microglia contribute to CNS homeostasis during development and throughout adulthood. We discuss the heterogeneity of microglial phenotypes in the context of CNS disorders with an emphasis on neurodegenerative diseases, demyelinating diseases, CNS trauma, and epilepsy. We conclude this review with a discussion about the disease-specific heterogeneity of microglial function and how it could be exploited for therapeutic intervention.
topic	Microglial activation Phenotypes Homeostasis Heterogeneity CNS disorders
url	http://www.sciencedirect.com/science/article/pii/S1347861320300682
work_keys_str_mv	AT oluwaseunfatoba microgliaastherapeutictargetincentralnervoussystemdisorders AT takahideitokazu microgliaastherapeutictargetincentralnervoussystemdisorders AT toshihideyamashita microgliaastherapeutictargetincentralnervoussystemdisorders
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Microglia as therapeutic target in central nervous system disorders

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