Aberrant Methylation of APAF-1 Gene in Acute Myeloid Leukemia Patients

Aberrant Methylation of APAF-1 Gene in Acute Myeloid Leukemia Patients

Background: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Various genetic and epigenetic factors have been found to be influential in such patients. Methylation silencing of APAF-1, a putative tumor supp...

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Bibliographic Details
Main Authors: Shahrbano Rostami, Fatemeh Nadali, Reza Alibakhshi, Farhad Zaker, Nahid Nasiri, Mehrdad Payandeh, Bahram Chahardouli, Ali Maleki
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2016-12-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Acute myeloid leukemia
Epigenetics
Methylation
APAF-1
MSP
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/713

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