Low-Density Granulocytes Affect T-SPOT.TB Assay by Inhibiting the Production of Interferon-γ in T Cells via PD-L1/PD-1 Pathway

Low-Density Granulocytes Affect T-SPOT.TB Assay by Inhibiting the Production of Interferon-γ in T Cells via PD-L1/PD-1 Pathway

BackgroundT-SPOT TB (T-SPOT) assay is widely used for detection of Mycobacterium tuberculosis infection that is based on the detection of M. tuberculosis-specific interferon-γ-secreting T cells (ISCs) in peripheral blood mononuclear cells (PBMCs). Recently, high frequencies of low-density granulocyt...

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Bibliographic Details
Main Authors: Jiayue Rao, Rigu Su, Yiping Peng, Yang Guo, Zikun Huang, Yutao Ye, Yujie Gao, Jun Liu, Lu Zhang, Qing Luo, Junming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
low-density granulocytes
T-SPOT.TB
programmed death ligand 1
tuberculosis
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.622389/full

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