CoQ10 and Aging

• Main Authors: Isabella Peixoto de Barcelos, Richard H. Haas
• Format: Article
• Language: English
• Published: MDPI AG 2019-05-01
• Series: Biology
• Subjects: coenzyme Q10; aging; age-related diseases; mitochondrial dysfunction
• Online Access: https://www.mdpi.com/2079-7737/8/2/28

The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production. Oxidative damage to macromolecules including DNA and electron transport proteins likely increases ROS production resulting in further damage. This oxidative theory of cell aging is supported by the fact that diseases associated with the aging process are marked by increased oxidative stress. Coenzyme Q10 (CoQ₁₀) levels fall with aging in the human but this is not seen in all species or all tissues. It is unknown whether lower CoQ₁₀ levels have a part to play in aging and disease or whether it is an inconsequential cellular response to aging. Despite the current lay public interest in supplementing with CoQ₁₀, there is currently not enough evidence to recommend CoQ₁₀ supplementation as an anti-aging anti-oxidant therapy.