Clinical value of anti-HBc quantification for chronic HBV infection

• Main Authors: HOU Fengqin, WANG Guiqiang
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2018-05-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: hepatitis B antibodies; hepatitis B; chronic; alanine transaminase
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=9066

As the achivement of a major project during the 12th Five-year Plan Period in China, the technique of anti-HBc quantification has been approved for commercial use and holds promise for wide application in clinical practice. Chinese scholars have explored the clinical significance of anti-HBc in various aspects and found that it has great values in the assessment of natural course of chronic hepatitis B virus (HBV) infection and the baseline prediction of antiviral therapy. Studies have shown that anti-HBc is significantly positively correlated with alanine aminotransferase (ALT) and significantly associated with liver inflammation. In chronic HBV infection patients with a normal ALT level, anti-HBc can be used instead as an indicator, with great significance for the development of therapeutic strategy in such patients.