Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Objective: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. Methods: We utilize flux balance c...

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Bibliographic Details
Main Authors:	Christopher Nogiec, Alison Burkart, Jonathan M. Dreyfuss, Carles Lerin, Simon Kasif, Mary-Elizabeth Patti
Format:	Article
Language:	English
Published:	Elsevier 2015-03-01
Series:	Molecular Metabolism
Subjects:	Muscle insulin resistance Muscle metabolism Flux balance analysis Computational modeling
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877814002257

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