MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer

MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer

Abstract Background Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However, adverse reactions and accumulating resistance to radiation therapy require further investigation. Methods The expression levels of mitogen-activ...

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Bibliographic Details
Main Authors: Shuzhen Tian, Lili Lou, Mengyuan Tian, Guangping Lu, Jianghua Tian, Xi Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cervical cancer
MAPK4
AKT phosphorylation
DNA double-chain breakage
Radiation sensitivity
PARP1 inhibitors
Online Access:http://link.springer.com/article/10.1186/s13046-020-01644-5

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