KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human populat...

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Bibliographic Details
Main Authors: Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila, Francesca Fortini, Claudia Fornelli, Alessia Zotta, Alessia S. Cento, Andrea Perrelli, Enrica Boda, Antonio Pannuti, Saverio Marchi, Paolo Pinton, Roberto Ferrari, Paola Rizzo, Saverio Francesco Retta
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
cerebral cavernous malformation (ccm)
krit1
endothelial dysfunction (ed)
notch signaling
notch1
oxidative stress
ros
atherosclerosis
vcam-1
icam-1
Online Access:https://www.mdpi.com/1422-0067/20/19/4930

Internet

https://www.mdpi.com/1422-0067/20/19/4930

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