RAS, Cellular Plasticity, and Tumor Budding in Colorectal Cancer

RAS, Cellular Plasticity, and Tumor Budding in Colorectal Cancer

The high morbidity and mortality of colorectal cancer (CRC) remain a worldwide challenge, despite the advances in prevention, diagnosis, and treatment. RAS alterations have a central role in the pathogenesis of CRC universally recognized both in the canonical mutation-based classification and in the...

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Bibliographic Details
Main Authors: Valeria Maffeis, Lorenzo Nicolè, Rocco Cappellesso
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
RAS
colorectal cancer
plasticity
epithelial to mesenchymal transition
tumor budding
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01255/full

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