Computational Optimization of Bioanalytical Parameters for the Evaluation of the Toxicity of the Phytomarker 1,4 Napthoquinone and its Metabolite 1,2,4-trihydroxynapththalene

Computational Optimization of Bioanalytical Parameters for the Evaluation of the Toxicity of the Phytomarker 1,4 Napthoquinone and its Metabolite 1,2,4-trihydroxynapththalene

Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 na...

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Bibliographic Details
Main Authors: Velmani Gopal, Mohammad Harun AL Rashid, Sayani Majumder, Partha Pratim Maiti, Subhash C Mandal
Format: Article
Language:English
Published: Korean Pharmacopuncture Institute 2015-06-01
Series:Journal of Pharmacopuncture
Subjects:
autodock
DT-diaphorase
hydrogen peroxide
lawsone
NADPH
THN
Online Access:http://dx.doi.org/10.3831/KPI.2015.18.010

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