Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the...

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Main Authors:	Negar Seyed, Sima Rafati
Format:	Article
Language:	English
Published:	Pasteur Institute of Iran 2016-07-01
Series:	Journal of Medical Microbiology and Infectious Diseases
Subjects:	innate immunity neutrophil leishmania vaccine
Online Access:	http://jommid.pasteur.ac.ir/article-1-128-en.html

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spelling	doaj-7eb25cbfd334442fb2edad95391047632021-02-23T07:58:38ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302016-07-01433944Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine DesignNegar Seyed0Sima Rafati1 Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the adaptive response. Leishmania as an obligatory intracellular parasite has evolved to benefit this early innate response to find its way into macrophages, the final host cells. Therefore it is important to reconsider the role of neutrophils for further improvement of the current vaccine status.http://jommid.pasteur.ac.ir/article-1-128-en.htmlinnate immunityneutrophilleishmaniavaccine
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Negar Seyed Sima Rafati
spellingShingle	Negar Seyed Sima Rafati Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design Journal of Medical Microbiology and Infectious Diseases innate immunity neutrophil leishmania vaccine
author_facet	Negar Seyed Sima Rafati
author_sort	Negar Seyed
title	Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
title_short	Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
title_full	Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
title_fullStr	Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
title_full_unstemmed	Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
title_sort	innate immunity plays a key role in leishmania infection: implications for vaccine design
publisher	Pasteur Institute of Iran
series	Journal of Medical Microbiology and Infectious Diseases
issn	2345-5349 2345-5330
publishDate	2016-07-01
description	Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the adaptive response. Leishmania as an obligatory intracellular parasite has evolved to benefit this early innate response to find its way into macrophages, the final host cells. Therefore it is important to reconsider the role of neutrophils for further improvement of the current vaccine status.
topic	innate immunity neutrophil leishmania vaccine
url	http://jommid.pasteur.ac.ir/article-1-128-en.html
work_keys_str_mv	AT negarseyed innateimmunityplaysakeyroleinleishmaniainfectionimplicationsforvaccinedesign AT simarafati innateimmunityplaysakeyroleinleishmaniainfectionimplicationsforvaccinedesign
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Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

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