Role of AP-2α and MAPK7 in the regulation of autocrine TGF-β/miR-200b signals to maintain epithelial-mesenchymal transition in cholangiocarcinoma

Role of AP-2α and MAPK7 in the regulation of autocrine TGF-β/miR-200b signals to maintain epithelial-mesenchymal transition in cholangiocarcinoma

Abstract Background Cholangiocarcinoma (CCA) is characterized by early lymphatic, metastasis, and low survival rate. Epithelial-mesenchymal transition (EMT) is able to induce tumor metastasis. Although the TGF-β/miR-200 signals promote EMT in various types of cancer, the regulatory mechanism in CCA...

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Bibliographic Details
Main Authors: Dawei Zhang, Haiyan Li, Xiaofeng Jiang, Liangqi Cao, Zilong Wen, Xuewei Yang, Ping Xue
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Hematology & Oncology
Subjects:
TGF-β
miR-200b
AP-2α
MAPK7
EMT
Cholangiocarcinoma
Online Access:http://link.springer.com/article/10.1186/s13045-017-0528-6

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