Untargeted metabolomics reveals distinct metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations.

Untargeted metabolomics reveals distinct metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations.

Tumour angiogenesis is an important hallmark of cancer and the study of its metabolic adaptations, downstream to any cellular change, can reveal attractive targets for inhibiting cancer growth. In the tumour microenvironment, endothelial cells (ECs) interact with heterogeneous tumour cell types that...

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Bibliographic Details
Main Authors: Anusha Jayaraman, Praveen Kumar, Silvia Marin, Pedro de Atauri, Francesca Mateo, Timothy M Thomson, Josep J Centelles, Stewart F Graham, Marta Cascante
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5821452?pdf=render

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http://europepmc.org/articles/PMC5821452?pdf=render

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