Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial d...
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Bibliographic Details
| Main Authors: |
Jody Vykoukal,
Johannes F. Fahrmann,
Justin R. Gregg,
Zhe Tang,
Spyridon Basourakos,
Ehsan Irajizad,
Sanghee Park,
Guang Yang,
Chad J. Creighton,
Alia Fleury,
Jeffrey Mayo,
Adriana Paulucci-Holthauzen,
Jennifer B. Dennison,
Eunice Murage,
Christine B. Peterson,
John W. Davis,
Jeri Kim,
Samir Hanash,
Timothy C. Thompson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17645-z
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