Unsubstituted Oximes as Potential Therapeutic Agents

• Main Authors: Alicja K. Surowiak, Stanisław Lochyński, Daniel J. Strub
• Format: Article
• Language: English
• Published: MDPI AG 2020-04-01
• Series: Symmetry
• Subjects: oximes; OP poisoning; antimicrobial; biological activity
• Online Access: https://www.mdpi.com/2073-8994/12/4/575

Oximes, which are highly bioactive molecules, have versatile uses in the medical sector and have been indicated to possess biological activity. Certain oximes exist in nature in plants and animals, but they are also obtained by chemical synthesis. Oximes are known for their anti-inflammatory, antimicrobial, antioxidant and anticancer activities. Moreover, they are therapeutic agents against organophosphate (OP) poisoning. Two oximes are already commonly used in therapy. Due to these abilities, new oxime compounds have been synthesized, and their biological activity has been verified. Often, modification of carbonyl compounds into oximes leads to increased activity. Nevertheless, in some cases, oxime activity is connected to the activity of the substrate. Recent works have revealed that new oxime compounds can demonstrate such functions and thus are considered to be potential drugs for pathogenic diseases, as adjuvant therapy in various types of cancer and inflammation and as potential next-generation drugs against OP poisoning.