BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

Cancer mutational signatures have been associated with defects in genome maintenance pathways. Here the authors, by using a worm germline mutagenesis model defective of human orthologue BRCA-1, identify polymerase theta-mediated end-joining (TMEJ) as causing the BRCAness mutational signature.

Bibliographic Details
Main Authors: J. A. Kamp, R. van Schendel, I. W. Dilweg, M. Tijsterman
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17455-3
Description
Summary:Cancer mutational signatures have been associated with defects in genome maintenance pathways. Here the authors, by using a worm germline mutagenesis model defective of human orthologue BRCA-1, identify polymerase theta-mediated end-joining (TMEJ) as causing the BRCAness mutational signature.
ISSN:2041-1723

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