Effect of different dose of lidocaine on etomidate-induced myoclonus during general anesthesia induction

• Main Author: Xiao-Li Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-04-01
• Series: Journal of Hainan Medical University
• Subjects: Myoclonus; Etomidate; Lidocaine; Hemodynamics; Inflammation; Stress
• Online Access: http://www.hnykdxxb.com/PDF/201607/25.pdf

Objective: To study the effect of different dose of lidocaine on etomidate-induced myoclonus during general anesthesia induction. Methods: A total of 105 cases who received surgery under general anesthesia were selected for study and randomly divided into A, B and C group who received intravenous injection of 20 mg, 40 mg and 0 mg lidocaine during anesthesia induction respectively, then number of cases and degree of myoclonus were compared among three groups, and hemodynamic indexes, inflammation indexes and stress indexes during induction process were evaluated. Results: The number of cases of myoclonus 0 grade of A group and B group was significantly more than that of C group, the number of cases of myoclonus 1 grade, 2 grade and 3 grade was significantly less than that of C group, and the number of cases of myoclonus 0 grade, 1 grade, 2 grade and 3 grade of A group was not sinificantly different from that of B group. There was no difference in HR and MBP at T1-T4 points in time within A group, HR and MBP at T2-T4 points in time within B group were significantly lower than those at T1 point in time, and HR and MBP at T2-T4 points in time within C group were significantly higher than those at T1 point in time. During anesthesia induction, serum hs-CRP, HMGB-1, NE and E contents all showed increasing trend, and the increasing trend of hs-CRP, HMGB-1, NE and E contents of A group and B group was weaker than that of C group. Conclusions: Both 20 mg and 40 mg lidocaine can effectively reduce the incidence of etomidate-induced myoclonus and also alleviate inflammatory and stress response during anesthesia induction; 20 mg lidocaine has less influence on hemodynamics and is a more ideal dose for prevention of etomidate-induced myoclonus.