Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however,...

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Bibliographic Details
Main Authors: Effi Haque, M. Rezaul Karim, Aamir Salam Teeli, Magdalena Śmiech, Paweł Leszczynski, Dawid Winiarczyk, Emil D. Parvanov, Atanas G. Atanasov, Hiroaki Taniguchi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
NF-E2-related factor 2
transcription factor
redox homeostasis
oxidative stress
hepatocellular carcinoma
Online Access:https://www.mdpi.com/1422-0067/21/15/5378

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