Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats

<p>Abstract</p> <p>Background</p> <p>Subchronic administration of the potent pharmaceutical estrogen diethylstilbestrol (DES) to female Fischer 344 (F344) rats induces growth of large, hemorrhagic pituitaries that progress to tumors. Phytoestrogens (dietary plant estrog...

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Bibliographic Details
Main Authors: Kaphalia Bhupendra S, Nauduri Dhananjaya, Kochukov Mikhail, Jeng Yow-Jiun, Watson Cheryl S
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Nutrition & Metabolism
Online Access:http://www.nutritionandmetabolism.com/content/7/1/40