PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis

Vanderplow et al.1 report decreased PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits. Understanding how cognition differs between these BD subtypes clinically and biologically remains a challenge.

Bibliographic Details
Main Authors: Jelena Radulovic, Vilma Gabbay
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001105
Description
Summary:Vanderplow et al.1 report decreased PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits. Understanding how cognition differs between these BD subtypes clinically and biologically remains a challenge.
ISSN:2666-3791