Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases

Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases

Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericid...

Full description

Bibliographic Details
Main Authors: Eric Gomez, Martha Sanchez, Zonaira Gul, Carl Urban, Noriel Mariano, Robert H. K. Eng, David B. Huang, Tom Chiang
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2011/659769
id doaj-7e7f3afb9341488f8bd107d2223a165b
record_format Article
spelling doaj-7e7f3afb9341488f8bd107d2223a165b2020-11-24T22:34:56ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/659769659769Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 CasesEric Gomez0Martha Sanchez1Zonaira Gul2Carl Urban3Noriel Mariano4Robert H. K. Eng5David B. Huang6Tom Chiang7Infectious Disease Division, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USAInfectious Disease Division, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USAInfectious Disease Division, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USAInfectious Disease Division, Department of Medicine, New York Hospital Queens, Flushing, NY 11355, USAInfectious Disease Division, Department of Medicine, New York Hospital Queens, Flushing, NY 11355, USAInfectious Disease Division, Department of Medicine, VA New Jersey Health Care System, 385 Tremont Avenue, 111-ID, East Orange, NJ 07018, USAInfectious Disease Division, Department of Medicine, VA New Jersey Health Care System, 385 Tremont Avenue, 111-ID, East Orange, NJ 07018, USAInfectious Disease Division, Department of Medicine, VA New Jersey Health Care System, 385 Tremont Avenue, 111-ID, East Orange, NJ 07018, USAManagement of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients.http://dx.doi.org/10.1155/2011/659769
collection DOAJ
language English
format Article
sources DOAJ
author Eric Gomez
Martha Sanchez
Zonaira Gul
Carl Urban
Noriel Mariano
Robert H. K. Eng
David B. Huang
Tom Chiang
spellingShingle Eric Gomez
Martha Sanchez
Zonaira Gul
Carl Urban
Noriel Mariano
Robert H. K. Eng
David B. Huang
Tom Chiang
Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
Case Reports in Medicine
author_facet Eric Gomez
Martha Sanchez
Zonaira Gul
Carl Urban
Noriel Mariano
Robert H. K. Eng
David B. Huang
Tom Chiang
author_sort Eric Gomez
title Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_short Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_full Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_fullStr Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_full_unstemmed Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_sort polymyxin combination therapy and the use of serum bactericidal titers in the management of kpc-producing klebsiella pneumoniae infections: a report of 3 cases
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2011-01-01
description Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients.
url http://dx.doi.org/10.1155/2011/659769
work_keys_str_mv AT ericgomez polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT marthasanchez polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT zonairagul polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT carlurban polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT norielmariano polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT roberthkeng polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT davidbhuang polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
AT tomchiang polymyxincombinationtherapyandtheuseofserumbactericidaltitersinthemanagementofkpcproducingklebsiellapneumoniaeinfectionsareportof3cases
_version_ 1725725643594792960

Similar Items