Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis

Background: The available evidence on the effects of daylight saving time (DST) transitions on major cardiovascular diseases is limited and conflicting. We carried out the first meta-analysis aimed at evaluating the risk of acute myocardial infarction (AMI) following DST transitions. Methods: We sea...

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Main Authors: Roberto Manfredini, Fabio Fabbian, Rosaria Cappadona, Alfredo De Giorgi, Francesca Bravi, Tiziano Carradori, Maria Elena Flacco, Lamberto Manzoli
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/8/3/404
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spelling doaj-7e7ac442694246fd90aa2ecc6ba09e6f2020-11-24T21:20:57ZengMDPI AGJournal of Clinical Medicine2077-03832019-03-018340410.3390/jcm8030404jcm8030404Daylight Saving Time and Acute Myocardial Infarction: A Meta-AnalysisRoberto Manfredini0Fabio Fabbian1Rosaria Cappadona2Alfredo De Giorgi3Francesca Bravi4Tiziano Carradori5Maria Elena Flacco6Lamberto Manzoli7Faculty of Medicine, Surgery and Prevention, University of Ferrara, via Ludovico Ariosto 35, 44121 Ferrara, ItalyFaculty of Medicine, Surgery and Prevention, University of Ferrara, via Ludovico Ariosto 35, 44121 Ferrara, ItalyFaculty of Medicine, Surgery and Prevention, University of Ferrara, via Ludovico Ariosto 35, 44121 Ferrara, ItalyAzienda Ospedaliero-Universitaria ‘S. Anna’, Via Aldo Moro 8, 44123 Ferrara, ItalyAzienda Ospedaliero-Universitaria ‘S. Anna’, Via Aldo Moro 8, 44123 Ferrara, ItalyAzienda Ospedaliero-Universitaria ‘S. Anna’, Via Aldo Moro 8, 44123 Ferrara, ItalyRegional Healthcare Agency of Abruzzo, via Attilio Monti 9, 65127 Pescara, ItalyFaculty of Medicine, Surgery and Prevention, University of Ferrara, via Ludovico Ariosto 35, 44121 Ferrara, ItalyBackground: The available evidence on the effects of daylight saving time (DST) transitions on major cardiovascular diseases is limited and conflicting. We carried out the first meta-analysis aimed at evaluating the risk of acute myocardial infarction (AMI) following DST transitions. Methods: We searched cohort or case-control studies evaluating the incidence of AMI, among adults (≥18 y), during the weeks following spring and/or autumn DST shifts, versus control periods. The search was made in MedLine and Scopus, up to 31 December 2018, with no language restriction. A summary odds ratio of AMI was computed after: (1) spring, (2) autumn or (3) both transitions considered together. Meta-analyses were also stratified by gender and age. Data were combined using a generic inverse-variance approach. Results: Seven studies (>115,000 subjects) were included in the analyses. A significantly higher risk of AMI (Odds Ratio: 1.03; 95% CI: 1.01–1.06) was observed during the two weeks following spring or autumn DST transitions. However, although AMI risk increased significantly after the spring shift (OR: 1.05; 1.02–1.07), the incidence of AMI during the week after winter DST transition was comparable with control periods (OR 1.01; 0.98–1.04). No substantial differences were observed when the analyses were stratified by age or gender. Conclusion: The risk of AMI increases modestly but significantly after DST transitions, supporting the proposal of DST shifts discontinuation. Additional studies that fully adjust for potential confounders are required to confirm the present findings.https://www.mdpi.com/2077-0383/8/3/404daylight saving timecircadian rhythmchronobiologyacute myocardial infarctionmeta-analysis
collection DOAJ
language English
format Article
sources DOAJ
author Roberto Manfredini
Fabio Fabbian
Rosaria Cappadona
Alfredo De Giorgi
Francesca Bravi
Tiziano Carradori
Maria Elena Flacco
Lamberto Manzoli
spellingShingle Roberto Manfredini
Fabio Fabbian
Rosaria Cappadona
Alfredo De Giorgi
Francesca Bravi
Tiziano Carradori
Maria Elena Flacco
Lamberto Manzoli
Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
Journal of Clinical Medicine
daylight saving time
circadian rhythm
chronobiology
acute myocardial infarction
meta-analysis
author_facet Roberto Manfredini
Fabio Fabbian
Rosaria Cappadona
Alfredo De Giorgi
Francesca Bravi
Tiziano Carradori
Maria Elena Flacco
Lamberto Manzoli
author_sort Roberto Manfredini
title Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
title_short Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
title_full Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
title_fullStr Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
title_full_unstemmed Daylight Saving Time and Acute Myocardial Infarction: A Meta-Analysis
title_sort daylight saving time and acute myocardial infarction: a meta-analysis
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2019-03-01
description Background: The available evidence on the effects of daylight saving time (DST) transitions on major cardiovascular diseases is limited and conflicting. We carried out the first meta-analysis aimed at evaluating the risk of acute myocardial infarction (AMI) following DST transitions. Methods: We searched cohort or case-control studies evaluating the incidence of AMI, among adults (≥18 y), during the weeks following spring and/or autumn DST shifts, versus control periods. The search was made in MedLine and Scopus, up to 31 December 2018, with no language restriction. A summary odds ratio of AMI was computed after: (1) spring, (2) autumn or (3) both transitions considered together. Meta-analyses were also stratified by gender and age. Data were combined using a generic inverse-variance approach. Results: Seven studies (>115,000 subjects) were included in the analyses. A significantly higher risk of AMI (Odds Ratio: 1.03; 95% CI: 1.01–1.06) was observed during the two weeks following spring or autumn DST transitions. However, although AMI risk increased significantly after the spring shift (OR: 1.05; 1.02–1.07), the incidence of AMI during the week after winter DST transition was comparable with control periods (OR 1.01; 0.98–1.04). No substantial differences were observed when the analyses were stratified by age or gender. Conclusion: The risk of AMI increases modestly but significantly after DST transitions, supporting the proposal of DST shifts discontinuation. Additional studies that fully adjust for potential confounders are required to confirm the present findings.
topic daylight saving time
circadian rhythm
chronobiology
acute myocardial infarction
meta-analysis
url https://www.mdpi.com/2077-0383/8/3/404
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