Suppression of Inflammatory Cardiac Cytokine Network in Rats with Untreated Obesity and Pre-Diabetes by AT2 Receptor Agonist NP-6A4

Suppression of Inflammatory Cardiac Cytokine Network in Rats with Untreated Obesity and Pre-Diabetes by AT2 Receptor Agonist NP-6A4

Obesity affects over 42% of the United States population and exacerbates heart disease, the leading cause of death in men and women. Obesity also increases pro-inflammatory cytokines that cause chronic tissue damage to vital organs. The standard-of-care does not sufficiently attenuate these inflamma...

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Bibliographic Details
Main Authors: Madhavi P. Gavini, Abuzar Mahmood, Anthony M. Belenchia, Paige Beauparlant, Senthil A. Kumar, Sivakumar Ardhanari, Vincent G. DeMarco, Lakshmi Pulakat
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
obesity
cardiac dysfunction
inflammatory cytokines
myocardial strain
AT2 receptor
heart disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.693167/full

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