Structural requirements for the procoagulant activity of nucleic acids.

Structural requirements for the procoagulant activity of nucleic acids.

Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo. Yet, no information on structural requirements for the procoagulant activity of nucleic acids is availa...

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Bibliographic Details
Main Authors: Julia Gansler, Miriam Jaax, Silke Leiting, Bettina Appel, Andreas Greinacher, Silvia Fischer, Klaus T Preissner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511531?pdf=render

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