Single-molecule mechanics of protein-labelled DNA handles

Single-molecule mechanics of protein-labelled DNA handles

DNA handles are often used as spacers and linkers in single-molecule experiments to isolate and tether RNAs, proteins, enzymes and ribozymes, amongst other biomolecules, between surface-modified beads for nanomechanical investigations. Custom DNA handles with varying lengths and chemical end-modific...

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Bibliographic Details
Main Authors: Vivek S. Jadhav, Dorothea Brüggemann, Florian Wruck, Martin Hegner
Format: Article
Language:English
Published: Beilstein-Institut 2016-01-01
Series:Beilstein Journal of Nanotechnology
Subjects:
DNA handles
optical tweezers
protein labels
single molecule
Online Access:https://doi.org/10.3762/bjnano.7.16

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