In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives

Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabiliti...

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Main Authors:	Mohammad Shoaib, Syed Wadood Ali Shah, Niaz Ali, Ismail Shah, Muhammad Naveed Umar, Shafiullah, Muhammad Ayaz, Muhammad Nawaz Tahir, Sohail Akhtar
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2015/516878

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spelling	doaj-7e596d5991a74f09b226f984d408ef292020-11-25T00:37:31ZengHindawi LimitedJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/516878516878In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone DerivativesMohammad Shoaib0Syed Wadood Ali Shah1Niaz Ali2Ismail Shah3Muhammad Naveed Umar4Shafiullah5Muhammad Ayaz6Muhammad Nawaz Tahir7Sohail Akhtar8Department of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Khyber Pakhtunkhwa 25000, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Chemistry, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanDepartment of Physics, University of Sargodha, Punjab 40100, PakistanDepartment of Statistics, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, PakistanFree radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2–F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay. The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.http://dx.doi.org/10.1155/2015/516878
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mohammad Shoaib Syed Wadood Ali Shah Niaz Ali Ismail Shah Muhammad Naveed Umar Shafiullah Muhammad Ayaz Muhammad Nawaz Tahir Sohail Akhtar
spellingShingle	Mohammad Shoaib Syed Wadood Ali Shah Niaz Ali Ismail Shah Muhammad Naveed Umar Shafiullah Muhammad Ayaz Muhammad Nawaz Tahir Sohail Akhtar In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives Journal of Chemistry
author_facet	Mohammad Shoaib Syed Wadood Ali Shah Niaz Ali Ismail Shah Muhammad Naveed Umar Shafiullah Muhammad Ayaz Muhammad Nawaz Tahir Sohail Akhtar
author_sort	Mohammad Shoaib
title	In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
title_short	In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
title_full	In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
title_fullStr	In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
title_full_unstemmed	In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives
title_sort	in vitro enzyme inhibition potentials and antioxidant activity of synthetic flavone derivatives
publisher	Hindawi Limited
series	Journal of Chemistry
issn	2090-9063 2090-9071
publishDate	2015-01-01
description	Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2–F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay. The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.
url	http://dx.doi.org/10.1155/2015/516878
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In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives

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