Dexmedetomidine inhibits the lipopolysaccharide‐stimulated inflammatory response in microglia through the pathway involving TLR4 and NF‐κB

Abstract To investigate the effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)‐induced neuroinflammation in BV2 microglia. BV2 microglial cells were treated with various concentrations of DEX (0, 1, 10, and 100 ng/mL) for 1 hour, and then incubated in the presence or absence of 0.1 μg/mL L...

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Bibliographic Details
Main Authors: Xue‐Yue Zhou, Jing Liu, Zhi‐Peng Xu, Qiang Fu, Pei‐Qi Wang, Hong Zhang
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
Online Access:https://doi.org/10.1002/kjm2.12112