Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo.

Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo.

The novel pandemic A (H1N1) virus was first identified in Mexico in April 2009 and quickly spread worldwide. Like all influenzas, the H1N1 strain-specific properties of replication, virulence, and pathogenicity are a result of the particular genomic sequence and concerted expression of multiple gene...

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Main Authors: Lili Xu, Linlin Bao, Jianfang Zhou, Dayan Wang, Wei Deng, Qi Lv, Yila Ma, Fengdi Li, Huihui Sun, Lingjun Zhan, Hua Zhu, Chunmei Ma, Yuelong Shu, Chuan Qin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3115934?pdf=render

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