Impact of genetic heterogeneity in polymerase of hepatitis B virus on dynamics of viral load and hepatitis B progression.

Impact of genetic heterogeneity in polymerase of hepatitis B virus on dynamics of viral load and hepatitis B progression.

OBJECTIVE: The hepatitis B virus (HBV)-polymerase region overlaps pre-S/S genes with high epitope density and plays an essential role in viral replication. We investigated whether genetic variation in the polymerase region determined long-term dynamics of viral load and the risk of hepatitis B progr...

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Bibliographic Details
Main Authors: Chi-Jung Huang, Chih-Feng Wu, Chia-Ying Lan, Feng-Yu Sung, Chih-Lin Lin, Chun-Jen Liu, Hsin-Fu Liu, Ming-Whei Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728348?pdf=render

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http://europepmc.org/articles/PMC3728348?pdf=render

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