1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in <i>Leishmania amazonensis</i> Promastigote: An in Vitro Antileishmanial and in Silico Pharmacokinetic Study

1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in <i>Leishmania amazonensis</i> Promastigote: An in Vitro Antileishmanial and in Silico Pharmacokinetic Study

The current standard treatment for leishmaniasis has remained the same for over 100 years, despite inducing several adverse effects and increasing cases of resistance. In this study we evaluated the in vitro antileishmanial activity of 1,4-disubstituted-1,2,3 triazole compounds and carried out in si...

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Bibliographic Details
Main Authors: Fernando Almeida-Souza, Verônica Diniz da Silva, Gabriel Xavier Silva, Noemi Nosomi Taniwaki, Daiana de Jesus Hardoim, Camilla Djenne Buarque, Ana Lucia Abreu-Silva, Kátia da Silva Calabrese
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
cytotoxicity
transmission electron microscopy
leishmaniasis
treatment
ADME
toxicity
Online Access:https://www.mdpi.com/1422-0067/21/18/6839

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